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Article

Linkage of type 2 diabetes to the glucokinase gene.

Lancet (London, England) - 30 May 1992

Hattersley A T, Turner R C, Permutt M A, Patel P, Tanizawa Y, Chiu K C, O'Rahilly S, Watkins P J, Wainscoat J S

Abstract excerpt

Maturity-onset diabetes of the young (MODY) is a subtype of type 2 diabetes that presents from the second decade and has an autosomal dominant mode of inheritance. We have investigated the glucokinase gene, a candidate gene for diabetes, in two MODY pedigrees. In a large 5-generation pedigree (BX) with 15 diabetic members, use of a microsatellite polymorphism revealed linkage of diabetes to the glucokinase locus...

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Identifiers

PMID: 1349989
DOI: 10.1016/0140-6736(92)91958-b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Linkage of type 2 diabetes to the glucokinase gene.PMID 1349989Read ↗

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Genetic basis of maturity-onset diabetes of the young.Semantic proximity Read ↗

Linkage analysis and molecular scanning of glucokinase gene in NIDDM families.Semantic proximity Read ↗

Maturity-onset diabetes of the young.Semantic proximity Read ↗

Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q.Semantic proximity Read ↗

Search for a third susceptibility gene for maturity-onset diabetes of the young. Studies with eleven candidate genes.Semantic proximity Read ↗

Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus.Semantic proximity Read ↗

Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Missense glucokinase mutation in maturity-onset diabetes of the young and mutation screening in late-onset diabetes.Semantic proximity Read ↗

Linkage analysis of glucokinase gene with NIDDM in Caucasian pedigrees.Semantic proximity Read ↗

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