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Article

No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians.

The Journal of clinical endocrinology and metabolism - 1 Feb 2000

Frayling T M, McCarthy M I, Walker M, Levy J C, O'Rahilly S, Hitman G A, Rao P V, Bennett A J, Jones E C, Menzel S, Ellard S, Hattersley A T

Abstract excerpt

Several studies have identified evidence for linkage between type 2 diabetes and the regions on chromosomes 12 and 20 containing the maturity-onset diabetes of the young (MODY) genes, hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-4alpha. Two studies examining the HNF-1alpha region have demonstrated evidence for linkage at genome-wide levels of significance, whereas four studies examining the HNF-4alpha...

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PMID: 10690901
DOI: 10.1210/jcem.85.2.6395

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No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians.PMID 10690901Read ↗

Variants in hepatocyte nuclear factor 4alpha are modestly associated with type 2 diabetes in Pima Indians.Semantic proximity Read ↗

Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.Semantic proximity Read ↗

Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs.Semantic proximity Read ↗

A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population.Semantic proximity Read ↗

Effect of common polymorphisms in the HNF4alpha promoter on susceptibility to type 2 diabetes in the French Caucasian population.Semantic proximity Read ↗

Linkage of Genetic Markers on Human Chromosomes 20 and 12 to NIDDM in Caucasian Sib Pairs With a History of Diabetic NephropathySemantic proximity Read ↗

New susceptibility locus for NIDDM is localized to human chromosome 20q.Semantic proximity Read ↗

Linkage and molecular scanning analyses of MODY3/hepatocyte nuclear factor-1 alpha gene in typical familial type 2 diabetes: evidence for novel mutations in exons 8 and 10.Semantic proximity Read ↗

Novel susceptibility gene for late-onset NIDDM is localized to human chromosome 12q.Semantic proximity Read ↗

Genetic analysis of HNF4A polymorphisms in Caucasian-American type 2 diabetes.Semantic proximity Read ↗

Association study on chromosome 20q11.21-13.13 locus and its contribution to type 2 diabetes susceptibility in Japanese.Semantic proximity Read ↗

Further evidence for a susceptibility locus for type 2 diabetes on chromosome 20q13.1-q13.2.Semantic proximity Read ↗

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