No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians.

doi:10.1210/jcem.85.2.6395

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Article

No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians.

The Journal of clinical endocrinology and metabolism - 1 Feb 2000

Frayling T M, McCarthy M I, Walker M, Levy J C, O'Rahilly S, Hitman G A, Rao P V, Bennett A J, Jones E C, Menzel S, Ellard S, Hattersley A T

Abstract excerpt

Several studies have identified evidence for linkage between type 2 diabetes and the regions on chromosomes 12 and 20 containing the maturity-onset diabetes of the young (MODY) genes, hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-4alpha. Two studies examining the HNF-1alpha region have demonstrated evidence for linkage at genome-wide levels of significance, whereas four studies examining the HNF-4alpha...

Topics

Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 20
Cohort Studies
DNA-Binding Proteins
Diabetes Mellitus, Type 2
Female
Genetic Linkage
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hepatocyte Nuclear Factor 1

Hepatocyte Nuclear Factor 1-alpha

Hepatocyte Nuclear Factor 1-beta

Hepatocyte Nuclear Factor 4

Humans

Male

Middle Aged

Nuclear Proteins

Phosphoproteins

Source

Open in PubMed

Identifiers

PMID: 10690901
DOI: 10.1210/jcem.85.2.6395

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No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians.PMID 10690901Read ↗

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