Article
No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes.
Diabetes - 1 May 2001
Dupont S, Hani E H, Cras-Méneur C, De Matos F, Lobbens S, Lecoeur C, Vaxillaire M, Scharfmann R, Froguel P
Abstract excerpt
Activins are members of the transforming growth factor-beta superfamily. They have a wide range of biological effects on cell growth and differentiation. For transmembrane signaling, activins bind directly to activin receptor type 2A (ACVR2A) or 2B (ACVR2B). Transgenic and knock-out mice for the ACVR2B gene display various endocrine pancreas-related abnormalities, including islet hypoplasia and glucose...
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