Linkage analysis of maturity-onset diabetes of the young (MODY): genetic heterogeneity and nonpenetrance.

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Article

Linkage analysis of maturity-onset diabetes of the young (MODY): genetic heterogeneity and nonpenetrance.

American journal of human genetics - 1 Mar 1992

Bowden D W, Akots G, Rothschild C B, Falls K F, Sheehy M J, Hayward C, Mackie A, Baird J, Brock D, Antonarakis S E

Abstract excerpt

We have analyzed the inheritance of maturity-onset diabetes of the young (MODY) on chromosome 20 in a large multigeneration family, the R.-W. family, and in two other MODY families. Of the four branches of the R.-W. pedigree which have been studied, two have documented early onset of non-insulin-dependent diabetes mellitus (NIDDM), while there is no evidence of early onset in the other two branches. The...

Topics

Adolescent
Adult
Age Factors
Chi-Square Distribution
Child
Child, Preschool
Chromosome Mapping
Chromosomes, Human, Pair 20
Crossing Over, Genetic
DNA Probes
Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Gene Expression

Gene Expression Regulation

Genetic Linkage

Genetic Variation

Genotype

Humans

Source

Open in PubMed Open full text

Identifiers

PMID: 1539597
PMCID: PMC1684280

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1539597-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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