Article
Interindividual variation in nucleotide excision repair genes and risk of endometrial cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2005
Weiss Jocelyn M, Weiss Noel S, Ulrich Cornelia M, Doherty Jennifer A, Voigt Lynda F, Chen Chu
Abstract excerpt
Exposure to estrogens is a likely cause of endometrial cancer, but the means by which estrogens exert this effect are not entirely clear. One hypothesis is that certain estrogen metabolites bind to the DNA, forming bulky adducts that damage the DNA and initiate carcinogenesis. A woman's reduced capacity to repair such damage may increase her risk of endometrial cancer. We conducted a population-based case-control...
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