Article
Polymorphisms in nucleotide excision repair genes and endometrial cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2011
Doherty Jennifer A, Weiss Noel S, Fish Sherianne, Fan Wenhong, Loomis Melissa M, Sakoda Lori C, Rossing Mary Anne, Zhao Lue Ping, Chen Chu
Abstract excerpt
BACKGROUND: Exposure to estrogens increases the risk of endometrial cancer. Certain estrogen metabolites can form bulky DNA adducts, which are removed via nucleotide excision repair (NER), and the ability to carry out this repair might be related to endometrial cancer risk. METHODS: We examined 64 tag and functional single-nucleotide polymorphisms (SNPs) in the NER genes ERCC1, ERCC2 (XPD), ERCC3 (XPB), ERCC4...
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