Article
Two estrogen-related variants in CYP19A1 and endometrial cancer risk: a pooled analysis in the Epidemiology of Endometrial Cancer Consortium.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2009
Setiawan Veronica Wendy, Doherty Jennifer A, Shu Xiao-Ou, Akbari Mohammad R, Chen Chu, De Vivo Immaculata, Demichele Angela, Garcia-Closas Montserrat, Goodman Marc T, Haiman Christopher A, Hankinson Susan E, Henderson Brian E, Horn-Ross Pamela L, Lacey James V, Le Marchand Loic, Levine Douglas A, Liang Xiaolin, Lissowska Jolanta, Lurie Galina, McGrath Monica, Narod Steven A, Rebbeck Timothy R, Ursin Giske, Weiss Noel S, Xiang Yong-Bing, Yang Hannah P, Zheng Wei, Olson Sara H
Abstract excerpt
Common variants in CYP19A1 (the A alleles of rs749292 and rs727479) have been associated with a 10% to 20% increase in circulating estrogen levels in postmenopausal women. We hypothesized that the presence of one or both A alleles in these single nucleotide polymorphisms (SNP) is associated with increased endometrial cancer risk. We tested this hypothesis in a large pooled analysis of 4,998 endometrial cancer...
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