Article
Polymorphisms of DNA repair genes in endometrial cancer.
Pathology oncology research : POR - 1 Oct 2012
Sobczuk Anna, Poplawski Tomasz, Blasiak Janusz
Abstract excerpt
Endometrial cancer belongs to the commonest malignancy in females. Its development may be associated with the high exposure of endometrium to exo- and endogenous estrogens. Estrogens produce DNA bulky adducts and oxidative base damages which are removed in nucleotide excision repair (NER) and base excision repair (BER) pathways. The reaction of endometrial cells to DNA damage may be crucial for their...
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