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Article

Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk.

American journal of epidemiology - 15 Nov 2009

Reding Kerryn W, Li Christopher I, Weiss Noel S, Chen Chu, Carlson Christopher S, Duggan David, Thummel Kenneth E, Daling Janet R, Malone Kathleen E

Abstract excerpt

The relevance of progesterone to breast carcinogenesis is highlighted by evidence indicating that use of combined estrogen-progesterone therapy (EPT) is more strongly related to breast cancer risk than is use of unopposed estrogen therapy. However, few investigators have assessed how genetic variation in progesterone-related genes modifies the effect of EPT on risk. In an analysis combining data from 2...

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Identifiers

PMID: 19846565
DOI: 10.1093/aje/kwp298
PMCID: PMC2781763

Genes

PGR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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