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Article

Disparate associations of a functional promoter polymorphism in PCK1 with carotid wall ultrasound traits.

Stroke - 1 Dec 2005

Hegele Robert A, Al-Shali Khalid Z, House Andrew A, Hanley Anthony J G, Harris Stewart B, Mamakeesick Mary, Fenster Aaron, Zinman Bernard, Cao Henian, Spence J David

Abstract excerpt

BACKGROUND AND PURPOSE: Cytosolic phosphoenolpyruvate carboxykinase (PEPCK; EC 4.1.1.32), encoded by PCK1, catalyzes the first committed step in gluconeogenesis. We previously showed that a -232C>G promoter polymorphism within a cis-acting element required for basal and cAMP-mediated PCK1 gene transcription results in loss of negative regulation by insulin, contributing to worsened metabolic control in the...

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Source

Identifiers

PMID: 16282543
DOI: 10.1161/01.STR.0000190833.43791.be

Genes

PCK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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