Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Large-scale study of the -232C > G polymorphism of PCK1 in Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association - 1 Oct 2006

Wegner L, Andersen G, Albrechtsen A, Sparsø T, Glümer C, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O

Abstract excerpt

AIMS: Phosphoenolpyruvate carboxykinase (PEPCK) is a catalyst of the rate-limiting step in the gluconeogenic pathway and is regulated at the transcriptional level predominantly by insulin, glucocorticoids, glucagon, and cAMP. The -232C > G polymorphism in the gene encoding PEPCK (PCK1) is reported to associate with Type 2 diabetes in Canadian Caucasians and Oji-Cree populations. We have estimated the impact of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Denmark

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to PGC gene

Share to Genetic Predisposition to Disease

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 16978381
DOI: 10.1111/j.1464-5491.2006.01926.x

Genes

PCK1
PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Large-scale study of the -232C > G polymorphism of PCK1 in Type 2 diabetes.PMID 16978381Read ↗

Association of the promoter polymorphism -232C/G of the phosphoenolpyruvate carboxykinase gene (PCK1) with Type 2 diabetes mellitus.Semantic proximity Read ↗

Promoter polymorphism in PCK1 (phosphoenolpyruvate carboxykinase gene) associated with type 2 diabetes mellitus.Semantic proximity Read ↗

The promoter polymorphism -232C/G of the PCK1 gene is associated with type 2 diabetes in a UK-resident South Asian population.Semantic proximity Read ↗

Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study).Semantic proximity Read ↗

Identification of a novel variant in the phosphoenolpyruvate carboxykinase gene promoter in Japanese patients with type 2 diabetes.Semantic proximity Read ↗

Association of a polymorphism in the gene encoding phosphoenolpyruvate carboxykinase 1 with high-density lipoprotein and triglyceride levels.Semantic proximity Read ↗

Variant screening of PRKAB2, a type 2 diabetes mellitus susceptibility candidate gene on 1q in Pima Indians.Semantic proximity Read ↗

Disparate associations of a functional promoter polymorphism in PCK1 with carotid wall ultrasound traits.Semantic proximity Read ↗

Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes.Semantic proximity Read ↗

Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits.Semantic proximity Read ↗

Genetic variation in UCP2 (uncoupling protein-2) is associated with energy metabolism in Pima Indians.Semantic proximity Read ↗

The effect of PCSK1 variants on waist, waist-hip ratio and glucose metabolism is modified by sex and glucose tolerance status.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.