Article
The promoter polymorphism -232C/G of the PCK1 gene is associated with type 2 diabetes in a UK-resident South Asian population.
BMC medical genetics - 2 Sept 2009
Rees Simon D, Britten Abigail C, Bellary Srikanth, O'Hare J Paul, Kumar Sudhesh, Barnett Anthony H, Kelly M Ann
Abstract excerpt
BACKGROUND: The PCK1 gene, encoding cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C), has previously been implicated as a candidate gene for type 2 diabetes (T2D) susceptibility. Rodent models demonstrate that over-expression of Pck1 can result in T2D development and a single nucleotide poly...
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