Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered aging-related thymic involution in T cell receptor transgenic, MHC-deficient, and CD4-deficient mice.

Mechanisms of ageing and development - 13 Mar 2000

Lau L L, Spain L M

Abstract excerpt

During aging in mice and humans, a gradual decline in thymus integrity and function occurs (thymic involution). To determine whether T cell reactivity or development affects thymic involution, we compared the thymic phenotype in old (12 months) and young (2 months) mice transgenic for rearranged alphabeta or beta 2B4 T cell receptor (TCR) genes, mice made deficient for CD4 by gene targetting (CD4(-/-)), mice made...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta 2-Microglobulin
Share to CD4 Antigens
Share to Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred DBA

Share to Organ Size

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Thymus Gland

Share to Transgenes

Source

Identifiers

PMID: 10799708
DOI: 10.1016/s0047-6374(00)00091-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered aging-related thymic involution in T cell receptor transgenic, MHC-deficient, and CD4-deficient mice.PMID 10799708Read ↗

Phenotypical and morphological changes in the thymic microenvironment from ageing mice.Semantic proximity Read ↗

The effect of age on the phenotype and function of developing thymocytes.Semantic proximity Read ↗

Premature thymic involution in young Foxn1lacz mutant mice causes peripheral T cell phenotypes similar to aging-induced immunosenescence.Semantic proximity Read ↗

Age-related thymic involution in C57BL/6J x DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10.Semantic proximity Read ↗

Gender‐Related Differences in the Rates of Age AssociatedThymic AtrophySemantic proximity Read ↗

Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development.Semantic proximity Read ↗

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages.Semantic proximity Read ↗

Age-related accumulation of T cells with markers of relatively stronger autoreactivity leads to functional erosion of T cells.Semantic proximity Read ↗

Transforming growth factor-beta2 is involved in quantitative genetic variation in thymic involution.Semantic proximity Read ↗

Immunosenescence is associated with altered gene expression and epigenetic regulation in primary and secondary immune organsSemantic proximity Read ↗

Dynamic Changes in Lymphocyte Populations Establish Zebrafish as a Thymic Involution ModelSemantic proximity Read ↗

A T-cell functional phenotype common among autoimmune-prone rodent strains.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.