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Article

Paternal Insulin-like Growth Factor 2 (Igf2) Regulates Stem Cell Activity During Adulthood.

EBioMedicine - 1 Feb 2017

Barroca Vilma, Lewandowski Daniel, Jaracz-Ros Agnieszka, Hardouin Sylvie-Nathalie

Abstract excerpt

Insulin-like Growth Factor 2 (IGF2) belongs to the IGF/Insulin pathway, a highly conserved evolutionarily network that regulates growth, aging and lifespan. Igf2 is highly expressed in the embryo and in cancer cells. During mouse development, Igf2 is expressed in all sites where hematopoietic stem cells (HSC) successively expand, then its expression drops at weaning and becomes undetectable when adult HSC have...

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Share to Adult Stem Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28007480
DOI: 10.1016/j.ebiom.2016.11.035
PMCID: PMC5233811

Genes

IGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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