Article
Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2006
Hasegawa Akihiro, Miki Takako, Hosokawa Hiroyuki, Hossain Mohammad B, Shimizu Chiori, Hashimoto Kahoko, Kimura Motoko Y, Yamashita Masakatsu, Nakayama Toshinori
Abstract excerpt
Age-related changes in lymphocytes are most prominent in the T cell compartment. There have been substantial numbers of reports on T cell function in aged mice and humans, such as on the production of Th1 and Th2 cytokines, but the results show considerable variation and contradictions. In the present study, we used 8- to 12-mo-old aging mice and a well-established in vitro Th1/Th2 cell differentiation culture...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.