Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chronic TNF in the aging microenvironment exacerbates Tet2 loss-of-function myeloid expansion

26 Jun 2024

Abstract excerpt

ABSTRACT: Somatic mutations in the TET2 gene occur more frequently with age, imparting an intrinsic hematopoietic stem cells (HSCs) advantage and contributing to a phenomenon termed clonal hematopoiesis of indeterminate potential (CHIP). Individuals with TET2-mutant CHIP have a higher risk of developing myeloid neoplasms and other aging-related conditions. Despite its role in unhealthy aging, the extrinsic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Chronic Lymphocytic Leukemia Research
Share to Myeloproliferative Neoplasms: Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38924753
DOI: 10.1182/bloodadvances.2023011833

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chronic TNF in the aging microenvironment exacerbates Tet2 loss-of-function myeloid expansionPMID 38924753Read ↗

An inflammatory environment containing TNFα favors Tet2-mutant clonal hematopoiesis.Semantic proximity Read ↗

Aging in the bone marrow: when hematopoiesis gets clonal.Semantic proximity Read ↗

Aging drives Tet2+/- clonal hematopoiesis via IL-1 signaling.Semantic proximity Read ↗

Human TET2-Mutant Clonal Hematopoiesis Expansion Is Driven by Distinct Inflammatory Signaling Responses in Stem Cells Versus Myeloid Progeny.Semantic proximity Read ↗

The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation.Semantic proximity Read ↗

Age-Associated TET2 Mutations: Common Drivers of Myeloid Dysfunction, Cancer and Cardiovascular Disease.Semantic proximity Read ↗

TET2 mutation as prototypic clonal hematopoiesis lesion.Semantic proximity Read ↗

Clonal hematopoiesis related TET2 loss-of-function impedes IL1β-mediated epigenetic reprogramming in hematopoietic stem and progenitor cellsSemantic proximity Read ↗

<i>Id1</i> Promotes Clonal Hematopoiesis in Mice with <i>Tet2</i> Loss of FunctionSemantic proximity Read ↗

The transcriptional and epigenetic reprogramming associated with chronic IL1β-mediated expansion and myeloid priming in TET2 deficient stem and progenitor cellsSemantic proximity Read ↗

TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and ObesitySemantic proximity Read ↗

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.