Base flipping in nucleotide excision repair.

Abstract excerpt

UvrB, the ultimate damage-binding protein in bacterial nucleotide excision repair is capable of binding a vast array of structurally unrelated lesions. A beta-hairpin structure in the protein plays an important role in damage-specific binding. In this paper we have monitored DNA conformational alterations in the UvrB-DNA complex, using the fluorescent adenine analogue 2-aminopurine. We show that binding of UvrB...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to 2-Aminopurine
• Share to Adenosine Diphosphate
• Share to DNA Helicases