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Article

Search for DNA damage by human alkyladenine DNA glycosylase involves early intercalation by an aromatic residue.

The Journal of biological chemistry - 29 Sept 2017

Hendershot Jenna M, O'Brien Patrick J

Abstract excerpt

DNA repair enzymes recognize and remove damaged bases that are embedded in the duplex. To gain access, most enzymes use nucleotide flipping, whereby the target nucleotide is rotated 180° into the active site. In human alkyladenine DNA glycosylase (AAG), the enzyme that initiates base excision repair of alkylated bases, the flipped-out nucleotide is stabilized by intercalation of the side chain of tyrosine 162...

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Identifiers

PMID: 28747435
DOI: 10.1074/jbc.M117.782813
PMCID: PMC5625039

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