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Article

Expression of dominant negative rab5 in HeLa cells regulates endocytic trafficking distal from the plasma membrane.

Experimental cell research - 1 Apr 2004

Dinneen Jennifer L, Ceresa Brian P

Abstract excerpt

Ligand-mediated endocytosis is an important regulatory mechanism of epidermal growth factor (EGF) receptor (EGFR) signal transduction. Coordinated EGFR internalization and degradation function to regulate the spatial and temporal components of EGFR-effector interactions. In an effort to better understand the molecular mechanisms that control these events, we examined the role of rab5 in the endocytic trafficking...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15023538
DOI: 10.1016/j.yexcr.2003.12.006

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Expression of dominant negative rab5 in HeLa cells regulates endocytic trafficking distal from the plasma membrane.PMID 15023538Read ↗

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