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Article

Effect of EGF-receptor tyrosine kinase inhibitor on Rab5 function during endocytosis.

Archives of biochemistry and biophysics - 1 Sept 2012

Jozic Ivan, Saliba Samar C, Barbieri M Alejandro

Abstract excerpt

Tyrosine autophosphorylation within the cytoplasmic tail of EGF-receptor is a key event, which in turn recruits several factors including Shc, Grb2 and Rin1 that are essential activities for receptor-mediated endocytosis and signaling. In this study, we demonstrated that treatment with AG1478, an EGF-receptor kinase inhibitor, blocked the formation of Rab5-positive endosomes as well as the activation of Rab5 upon...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22683472
DOI: 10.1016/j.abb.2012.05.023
PMCID: PMC3427926

Genes

EGF

Provenance

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