Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ARF promotes the degradation of the Epidermal Growth Factor Receptor by the lysosome.

Experimental cell research - 15 Sept 2018

Beaumont Anais, Dayde Delphine, Hatat Anne-Sophie, Barrial Celine, Perron Pascal, Eymin Beatrice, Gazzeri Sylvie

Abstract excerpt

Epidermal Growth Factor Receptor (EGFR) signaling regulates multiple cellular processes including proliferation, survival and apoptosis, and is attenuated by lysosomal receptor degradation. EGFR is a potent oncogene and activating mutations of EGFR are critical determinants of oncogenic transformation as well as therapeutic targets in non-small cell lung cancer. We previously demonstrated that wild type and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP-Ribosylation Factors
Share to Apoptosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carcinoma, Non-Small-Cell Lung

Share to Down-Regulation

Share to Epidermal Growth Factor

Share to ErbB Receptors

Share to Lysosomes

Share to Reading Frames

Source

Identifiers

PMID: 29959911
DOI: 10.1016/j.yexcr.2018.06.027

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ARF promotes the degradation of the Epidermal Growth Factor Receptor by the lysosome.PMID 29959911Read ↗

Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutantsSemantic proximity Read ↗

Aberrant trafficking of NSCLC-associated EGFR mutants through the endocytic recycling pathway promotes interaction with Src.Semantic proximity Read ↗

Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling.Semantic proximity Read ↗

Nuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor familySemantic proximity Read ↗

A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation.Semantic proximity Read ↗

Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis.Semantic proximity Read ↗

Endocytosis and cancer.Semantic proximity Read ↗

Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation.Semantic proximity Read ↗

rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosome.Semantic proximity Read ↗

Reactivation of Mutant-EGFR Degradation through Clathrin Inhibition Overcomes Resistance to EGFR Tyrosine Kinase Inhibitors.Semantic proximity Read ↗

The Arf-family protein, Arl8b, is involved in the spatial distribution of lysosomes.Semantic proximity Read ↗

Regulated lysosomal exocytosis mediates cancer progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.