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Article

The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription.

The EMBO journal - 16 Nov 2005

Parker Mathew J, Licence Steve, Erlandsson Lena, Galler Gunther R, Chakalova Lyubomira, Osborne Cameron S, Morgan Geoff, Fraser Peter, Jumaa Hassan, Winkler Thomas H, Skok Jane, Mårtensson Inga-Lill

Abstract excerpt

The pre-B-cell receptor (pre-BCR), composed of Ig heavy and surrogate light chain (SLC), signals pre-BII-cell proliferative expansion. We have investigated whether the pre-BCR also signals downregulation of the SLC genes (VpreB and lambda5), thereby limiting this expansion. We demonstrate that, as BM cells progress from the pre-BI to large pre-BII-cell stage, there is a shift from bi- to mono-allelic lambda5...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16281060
DOI: 10.1038/sj.emboj.7600850
PMCID: PMC1283949

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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