Article

Genome-Wide CRISPRi Screening Identifies XPO5 as a Regulator of B Cell Mutation and Fitness

2026-04-24

Abstract excerpt

The B cell receptor (BCR) is the defining factor of B lymphocyte identity and function, allowing for a robust adaptive immune response through antigen recognition. Strict regulation of BCR surface density dictates proper B cell signaling, immune regulation, and the prevention of malignancy, yet the factors regulating this density remain undefined. Here, we performed a genome-wide CRISPR interference (CRISPRi) scre...

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Literature Corpus work: 789a83f6-360c-5f28-9937-db878038bc8f
DOI: 10.64898/2026.04.22.720139

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Genome-Wide CRISPRi Screening Identifies XPO5 as a Regulator of B Cell Mutation and FitnessDOI 10.64898/2026.04.22.720139Read

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