Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of precursor B cell expansion but not allelic exclusion in VpreB1/VpreB2 double-deficient mice.

The Journal of experimental medicine - 19 Feb 2001

Mundt C, Licence S, Shimizu T, Melchers F, Mårtensson I L

Abstract excerpt

The pre-B cell receptor consists of immunoglobulin (Ig) mu heavy chains and surrogate light chain, i.e., the VpreB and lambda5 proteins. To analyze the role of the two VpreB proteins, mice lacking the VpreB1 and VpreB2 genes were generated. VpreB1(-/-) VpreB2(-/-) mice were impaired in their B cell development at the transition from pre-BI to large pre-BII cells. Pre-BII cells did not expand by proliferation,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Cells
Share to Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Light Chains

Share to Immunoglobulin M

Share to Lymphoid Tissue

Share to Receptors, Antigen, B-Cell

Share to Spleen

Source

Open in PubMed Open full text

Identifiers

PMID: 11181696
DOI: 10.1084/jem.193.4.435
PMCID: PMC2195903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of precursor B cell expansion but not allelic exclusion in VpreB1/VpreB2 double-deficient mice.PMID 11181696Read ↗

Only VpreB1, but not VpreB2, is expressed at levels which allow normal development of B cells.Semantic proximity Read ↗

The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription.Semantic proximity Read ↗

VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus.Semantic proximity Read ↗

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression.Semantic proximity Read ↗

VprBP Is Required for Efficient Editing and Selection of Igκ+ B Cells, but Is Dispensable for Igλ+ and Marginal Zone B Cell Maturation and Selection.Semantic proximity Read ↗

Surface mu heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components.Semantic proximity Read ↗

B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS.Semantic proximity Read ↗

The role of Ig beta in precursor B cell transition and allelic exclusion.Semantic proximity Read ↗

Agammaglobulinemia and absent B lineage cells in a patient lacking the p85α subunit of PI3KSemantic proximity Read ↗

Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner.Semantic proximity Read ↗

Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway.Semantic proximity Read ↗

Positive selection of natural poly-reactive B cells in the periphery occurs independent of heavy chain allelic inclusion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.