Article
Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 2008
Griswold Anthony J, Chang Karen T, Runko Alexander P, Knight Melanie A, Min Kyung-Tai
Abstract excerpt
Increased expression of the histone deacetylase sir2 has been reported to extend the life span of diverse organisms including yeast, Caenorhabditis elegans, and Drosophila melanogaster. A small molecule activator of Sir2, resveratrol, has also been suggested to extend the fitness and survival of these simple model organisms as well as mice fed high calorie diets. However, other studies in yeast have shown that...
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