Article
Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation.
Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 2005
Sato Akitsugu, Kono Tomohiro, Nakada Kazuto, Ishikawa Kaori, Inoue Shin-Ichi, Yonekawa Hiromichi, Hayashi Jun-Ichi
Abstract excerpt
Pathogenic mutations in mtDNAs have been shown to be responsible for expression of respiration defects and resultant expression of mitochondrial diseases. This study directly addressed the issue of gene therapy of mitochondrial diseases by using nuclear transplantation of zygotes of transmitochondria mice (mito-mice). Mito-mice expressed respiration defects and mitochondrial diseases due to accumulation of mtDNA...
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