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Mitochondrial replacement therapy and assisted reproductive technology: A paradigm shift toward treatment of genetic diseases in gametes or in early embryos

19 Sept 2018

Abstract excerpt

BACKGROUND: Recent technological development allows nearly complete replacement of the cytoplasm of egg/embryo, eliminating the transmission of undesired defective mitochondria (mutated mitochondrial DNA: mtDNA) for patients with inherited mitochondrial diseases, which is called mitochondrial replacement therapy (MRT). METHODS: We review and summarize the mitochondrial biogenesis and mitochondrial diseases, the...

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PMID: 30377395
DOI: 10.1002/rmb2.12230

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