Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of disease phenotypes of adult mito-mice carrying pathogenic mtDNA by bone marrow transplantation.

Human molecular genetics - 1 Jun 2006

Inoue Shin-Ichi, Ishikawa Kaori, Nakada Kazuto, Sato Akitsugu, Miyoshi Hiroyuki, Hayashi Jun-Ichi

Abstract excerpt

For directly addressing the issue of gene therapy of adult patients with mitochondrial diseases, we carried out bone marrow transplantation to adult mito-mice with mutated mtDNA and expressing respiration defects for improvement of disease phenotypes. We supposed that bone marrow cells transdiffe...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Bone Marrow Transplantation
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Therapy

Share to Immunohistochemistry

Share to In Situ Nick-End Labeling

Share to Mice, Transgenic

Share to Renal Insufficiency

Source

Identifiers

PMID: 16613898
DOI: 10.1093/hmg/ddl102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16613898-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of disease phenotypes of adult mito-mice carrying pathogenic mtDNA by bone marrow transplantation.PMID 16613898Read ↗

Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation.Semantic proximity Read ↗

Reverse genetic studies of mitochondrial DNA-based diseases using a mouse model.Semantic proximity Read ↗

Mitochondrial Transplantation in Mitochondrial Medicine: Current Challenges and Future Perspectives.Semantic proximity Read ↗

Mitochondrial transfer from mesenchymal stem cells: Mechanisms and functionsSemantic proximity Read ↗

Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells.Semantic proximity Read ↗

Selection of rodent species appropriate for mtDNA transfer to generate transmitochondrial mito-mice expressing mitochondrial respiration defects.Semantic proximity Read ↗

Pathogenic mitochondrial DNA-induced respiration defects in hematopoietic cells result in anemia by suppressing erythroid differentiation.Semantic proximity Read ↗

The innate immune system in host mice targets cells with allogenic mitochondrial DNA.Semantic proximity Read ↗

The mitochondria‒paraspeckle axis regulates the survival of transplanted stem cells under oxidative stress conditionsSemantic proximity Read ↗

Differentiation diversity of mouse parthenogenetic embryonic stem cells in chimeric mice.Semantic proximity Read ↗

Contribution of somatic mutations in the mitochondrial genome to the development of cancer and tolerance against anticancer drugs.Semantic proximity Read ↗

Bone marrow stem cell therapy partially ameliorates pathological consequences in livers of mice expressing mutant human α1-antitrypsin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.