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Article

Suppression of disease phenotypes of adult mito-mice carrying pathogenic mtDNA by bone marrow transplantation.

Human molecular genetics - 1 Jun 2006

Inoue Shin-Ichi, Ishikawa Kaori, Nakada Kazuto, Sato Akitsugu, Miyoshi Hiroyuki, Hayashi Jun-Ichi

Abstract excerpt

For directly addressing the issue of gene therapy of adult patients with mitochondrial diseases, we carried out bone marrow transplantation to adult mito-mice with mutated mtDNA and expressing respiration defects for improvement of disease phenotypes. We supposed that bone marrow cells transdifferentiated into various tissues, so that their transplantation would suppress disease phenotypes. The results showed...

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Identifiers

PMID: 16613898
DOI: 10.1093/hmg/ddl102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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