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Comparative analysis of different nuclear transfer techniques to prevent the transmission of mitochondrial DNA variants

22 Oct 2019

Abstract excerpt

Prevention of mitochondrial DNA (mtDNA) diseases may currently be possible using germline nuclear transfer (NT). However, scientific evidence to compare efficiency of different NT techniques to overcome mtDNA diseases is lacking. Here, we performed four types of NT, including first or second polar body transfer (PB1/2T), maternal spindle transfer (ST) and pronuclear transfer (PNT), using NZB/OlaHsd and B6D2F1...

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PMID: 31651030
DOI: 10.1093/molehr/gaz062

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