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Article

Production of mitochondrial DNA transgenic mice using zygotes.

Methods (San Diego, Calif.) - 1 Apr 2002

Inoue Kimiko, Ogura Atsuo, Hayashi Jun-Ichi

Abstract excerpt

Several animal models of human disease, which have been developed by random or targeted modifications of genomic DNA sequences, have furthered our understanding of pathogenesis and the development of therapeutics. However, these models have not facilitated studies on mitochondrial diseases, since modifications to mitochondrial DNA (mtDNA) sequences are not possible using current recombination techniques....

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Identifiers

PMID: 12054927
DOI: 10.1016/S1046-2023(02)00042-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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