Article
Mitochondrial Transplantation in Mitochondrial Medicine: Current Challenges and Future Perspectives.
International journal of molecular sciences - 19 Jan 2023
D'Amato Marco, Morra Francesca, Di Meo Ivano, Tiranti Valeria
Abstract excerpt
Mitochondrial diseases (MDs) are inherited genetic conditions characterized by pathogenic mutations in nuclear DNA (nDNA) or mitochondrial DNA (mtDNA). Current therapies are still far from being fully effective and from covering the broad spectrum of mutations in mtDNA. For example, unlike heteroplasmic conditions, MDs caused by homoplasmic mtDNA mutations do not yet benefit from advances in molecular approaches....
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