Article
Generation of mice deficient for macrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for multiple lectins.
Molecular and cellular biology - 1 Jul 2002
Onami Thandi M, Lin Meei-Yun, Page Dawne M, Reynolds Shirley A, Katayama Carol D, Marth Jamey D, Irimura Tatsuro, Varki Ajit, Varki Nissi, Hedrick Stephen M
Abstract excerpt
Macrophage receptors function in pattern recognition for the induction of innate immunity, in cellular communication to mediate the regulation of adaptive immune responses, and in the clearance of some glycosylated cells or glycoproteins from the circulation. They also function in homeostasis by initiating the engulfment of apoptotic cells. Evidence has suggested that macrophage receptors function to recognize...
Topics
- Animals
- Asialoglycoproteins
- Carrier Proteins
- Erythrocyte Aging
- Erythrocyte Count
- Erythropoiesis
- Female
- Gene Targeting
- Genetic Complementation Test
- Hematopoiesis