Article
Effect of H-2 genes on expression of HLA-B27 and Yersinia-induced arthritis.
Scandinavian journal of rheumatology. Supplement - 1 Jan 1990
Nickerson C L, Hogen K L, Luthra H S, David C S
Abstract excerpt
HLA-B*2705 transgenic mice were continuously backcrossed to mice of the B10 background with various haplotypes. A high level of expression of the HLA-B27 protein was detected on peripheral blood lymphocytes (PBLs) from mice homozygous for H-2b, H-2f, H-2s, H-2p, H-2r, and H-2k haplotypes by FACS analysis with the ME-1 antibody. A lower level of expression of B27 was observed on PBLs from H-2v mice. Little or no...
Topics
- Animals
- Arthritis, Infectious
- Chromosome Deletion
- Gene Expression
- Genes, MHC Class I
- Genetic Predisposition to Disease
- HLA-B27 Antigen
- Haplotypes
- Mice
- Mice, Transgenic
- Receptors, Antigen, T-Cell