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Article

Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease.

World journal of gastroenterology - 14 Oct 2005

Cox David-G, Crusius J-Bart-A, Peeters Petra-H-M, Bueno-de-Mesquita H-Bas, Pena A-Salvador, Canzian Federico

Abstract excerpt

AIM: Prostaglandin G/H synthase 2 (PTGS2 or COX2) is one of the key factors in the cellular response to inflammation. PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases (IBD). In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms. We aimed at...

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Identifiers

PMID: 16273614
DOI: 10.3748/wjg.v11.i38.6003
PMCID: PMC4436724

Genes

PTGS2

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