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Article

Genetic variability in key genes in prostaglandin E2 pathway (COX-2, HPGD, ABCC4 and SLCO2A1) and their involvement in colorectal cancer development.

PloS one - 1 Jan 2014

Pereira Carina, Queirós Sara, Galaghar Ana, Sousa Hugo, Pimentel-Nunes Pedro, Brandão Catarina, Moreira-Dias Luís, Medeiros Rui, Dinis-Ribeiro Mário

Abstract excerpt

The pro-carcinogenic effects of prostaglandin E2 (PGE2) in colonic mucosa are not only regulated by the rates between Cyclooxygenase-2 (COX-2) biosynthesis and 15-Hydroxyprostaglandin Dehydrogenase (15-PGDH)-dependent degradation but also the steady-state levels of PGE2 in extracellular microenvironment, maintained by key specific prostaglandin transporters, the Multidrug Resistance Protein (MRP4) (efflux...

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Source

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Identifiers

PMID: 24694755
DOI: 10.1371/journal.pone.0092000
PMCID: PMC3973663

Genes

ABCC4
HPGD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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