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Article

Endothelial nitric oxide synthase (NOS3) genetic variants, maternal smoking, vitamin use, and risk of human orofacial clefts.

American journal of epidemiology - 15 Dec 2005

Shaw Gary M, Iovannisci David M, Yang Wei, Finnell Richard H, Carmichael Suzan L, Cheng Suzanne, Lammer Edward J

Abstract excerpt

Orofacial clefts have been associated with maternal cigarette smoking and lack of folic acid supplementation (which results in higher plasma homocysteine concentrations). Because endothelial nitric oxide synthase (NOS3) activity influences homocysteine concentration and because smoking compromises NOS3 activity, genetic variation in NOS3 might interact with smoking and folic acid use in clefting risk. The authors...

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Source

Identifiers

PMID: 16269583
DOI: 10.1093/aje/kwi336

Genes

NOS3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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