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Article

Evidence that the risk of spina bifida is influenced by genetic variation at the NOS3 locus.

Birth defects research. Part A, Clinical and molecular teratology - 1 Mar 2004

Brown Karen S, Cook Michelle, Hoess Katy, Whitehead Alexander S, Mitchell Laura E

Abstract excerpt

BACKGROUND: There is substantial evidence that the risk of spina bifida, a malformation of the caudal neural tube, may be associated with maternal or embryonic disturbances in the folate-homocysteine metabolic axis. Hence, variants of genes that influence this pathway represent an intriguing group of candidate genes for spina bifida and other neural tube defects (NTD). A common variant of the gene for endothelial...

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Share to NOS3 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nitric Oxide Synthase Type III

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Source

Identifiers

PMID: 15039923
DOI: 10.1002/bdra.20002

Genes

NOS3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence that the risk of spina bifida is influenced by genetic variation at the NOS3 locus.PMID 15039923Read ↗

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