Article
Variants of NOS1, NOS2, and NOS3 genes in asthmatics.
Biochemical and biophysical research communications - 27 Jan 2000
Gao P S, Kawada H, Kasamatsu T, Mao X Q, Roberts M H, Miyamoto Y, Yoshimura M, Saitoh Y, Yasue H, Nakao K, Adra C N, Kun J F, Moro-oka S, Inoko H, Ho L P, Shirakawa T, Hopkin J M
Abstract excerpt
Nitric oxide (NO) gas concentrations are higher in expired air in asthmatics. NO is synthesized by three isoforms of NO synthase (NOS) encoded by three distinct genes, NOS1, NOS2, and NOS3. Genome-wide searches have identified linkages to asthma on chromosomes 7, 12, and 17 where these three genes are localized. No association study, however, has been reported to date. To test whether variants of NOS1, NOS2, and...
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