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Article

Genetic association analyses of nitric oxide synthase genes and neural tube defects vary by phenotype.

Birth defects research. Part B, Developmental and reproductive toxicology - 1 Oct 2013

Soldano Karen L, Garrett Melanie E, Cope Heidi L, Rusnak J Michael, Ellis Nathen J, Dunlap Kaitlyn L, Speer Marcy C, Gregory Simon G, Ashley-Koch Allison E

Abstract excerpt

Neural tube defects (NTDs) are caused by improper neural tube closure during the early stages of embryonic development. NTDs are hypothesized to have a complex genetic origin and numerous candidate genes have been proposed. The nitric oxide synthase 3 (NOS3) G594T polymorphism has been implicated in risk for spina bifida, and interactions between that single nucleotide polymorphism (SNP) and the...

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Identifiers

PMID: 24323870
DOI: 10.1002/bdrb.21079
PMCID: PMC4169175

Genes

MTHFR
NOS1
NOS2
NOS3

Variants

Provenance

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