Article
Common 894G>T single nucleotide polymorphism in the gene coding for endothelial nitric oxide synthase (eNOS) and risk of congenital heart defects.
Clinical chemistry and laboratory medicine - 1 Jan 2008
van Beynum Ingrid M, Mooij Christiaan, Kapusta Livia, Heil Sandra, den Heijer Martin, Blom Henk J
Abstract excerpt
BACKGROUND: Endothelial nitric oxide synthase (eNOS) produces nitric oxide, which plays a role in vasodilatation and in the regulation of cell growth and apoptosis. eNOS-deficient mice have impaired cardiac development resulting in congenital heart defects (CHDs). In humans, a single nucleotide polymorphism in the gene coding for eNOS (894G>T) is associated with birth defects. METHODS: We investigated the eNOS...
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