Article
Ligand-independent actions of the vitamin D receptor maintain hair follicle homeostasis.
Molecular endocrinology (Baltimore, Md.) - 1 Apr 2005
Skorija Kristi, Cox Megan, Sisk Jeanne M, Dowd Diane R, MacDonald Paul N, Thompson Catherine C, Demay Marie B
Abstract excerpt
Alopecia is a feature of vitamin D receptor (VDR) mutations in humans and in VDR null mice. This alopecia results from an inability to initiate the anagen phase of the hair cycle after follicle morphogenesis is complete. Thus, once the initial hair is shed it does not regrow. VDR expression in the epidermal component of the hair follicle, the keratinocyte, is critical for maintenance of the hair cycle. To...
Topics
- Alopecia
- Animals
- COS Cells
- Cells, Cultured
- Chlorocebus aethiops
- Down-Regulation
- Hair Follicle
- Homeostasis
- Keratinocytes
- Ligands
- Mice
- Mice, Transgenic
- Mutation
- Receptors, Calcitriol
- Transcription Factors