Physical and functional interaction between the vitamin D receptor and hairless corepressor, two proteins required for hair cycling.

doi:10.1074/jbc.M304886200

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Article

Physical and functional interaction between the vitamin D receptor and hairless corepressor, two proteins required for hair cycling.

The Journal of biological chemistry - 3 Oct 2003

Hsieh Jui-Cheng, Sisk Jeanne M, Jurutka Peter W, Haussler Carol A, Slater Stephanie A, Haussler Mark R, Thompson Catherine C

Abstract excerpt

Both the vitamin D receptor (VDR) and hairless (hr) genes play a role in the mammalian hair cycle, as inactivating mutations in either result in total alopecia. VDR is a nuclear receptor that functions as a ligand-activated transcription factor, whereas the hairless gene product (Hr) acts as a corepressor of both the thyroid hormone receptor (TR) and the orphan nuclear receptor, RORalpha. In the present study, we...

Topics

Animals
COS Cells
Cell Nucleus
Cloning, Molecular
Glutathione Transferase
Humans
In Situ Hybridization
Ligands
Mice
Mutation
Nuclear Receptor Subfamily 1, Group F, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Plasmids

Precipitin Tests

Protein Binding

Protein Structure, Tertiary

Proteins

RNA, Complementary

Source

Open in PubMed

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PMID: 12847098
DOI: 10.1074/jbc.M304886200

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Physical and functional interaction between the vitamin D receptor and hairless corepressor, two proteins required for hair cycling.PMID 12847098Read ↗

Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycle.Semantic proximity Read ↗

Hairless Suppresses Vitamin D Receptor Transactivation in Human KeratinocytesSemantic proximity Read ↗

The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor.Semantic proximity Read ↗

Interactions of the Vitamin D Receptor with the Corepressor HairlessSemantic proximity Read ↗

Ligand-independent actions of the vitamin D receptor maintain hair follicle homeostasis.Semantic proximity Read ↗

The co-repressor hairless has a role in epithelial cell differentiation in the skin.Semantic proximity Read ↗

Development and progression of alopecia in the vitamin D receptor null mouseSemantic proximity Read ↗

Lymphoid enhancer-binding factor-1 (LEF1) interacts with the DNA-binding domain of the vitamin D receptor.Semantic proximity Read ↗

Functional mapping of the mouse <i>hairless</i> gene promoter regionSemantic proximity Read ↗

Molecular and functional aspects of the hairless (hr) gene in laboratory rodents and humans.Semantic proximity Read ↗

Hairless and Wnt signaling: allies in epithelial stem cell differentiation.Semantic proximity Read ↗

The "bald Mill Hill" mutation in the mouse is associated with an abnormal, mislocalized HR bmh protein.Semantic proximity Read ↗

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