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Article

Physical and functional interaction between the vitamin D receptor and hairless corepressor, two proteins required for hair cycling.

The Journal of biological chemistry - 3 Oct 2003

Hsieh Jui-Cheng, Sisk Jeanne M, Jurutka Peter W, Haussler Carol A, Slater Stephanie A, Haussler Mark R, Thompson Catherine C

Abstract excerpt

Both the vitamin D receptor (VDR) and hairless (hr) genes play a role in the mammalian hair cycle, as inactivating mutations in either result in total alopecia. VDR is a nuclear receptor that functions as a ligand-activated transcription factor, whereas the hairless gene product (Hr) acts as a corepressor of both the thyroid hormone receptor (TR) and the orphan nuclear receptor, RORalpha. In the present study, we...

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Identifiers

PMID: 12847098
DOI: 10.1074/jbc.M304886200

Genes

VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Physical and functional interaction between the vitamin D receptor and hairless corepressor, two proteins required for hair cycling.PMID 12847098Read ↗

Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycle.Semantic proximity Read ↗

Hairless Suppresses Vitamin D Receptor Transactivation in Human KeratinocytesSemantic proximity Read ↗

The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor.Semantic proximity Read ↗

Interactions of the Vitamin D Receptor with the Corepressor HairlessSemantic proximity Read ↗

Ligand-independent actions of the vitamin D receptor maintain hair follicle homeostasis.Semantic proximity Read ↗

The co-repressor hairless has a role in epithelial cell differentiation in the skin.Semantic proximity Read ↗

Development and progression of alopecia in the vitamin D receptor null mouseSemantic proximity Read ↗

Lymphoid enhancer-binding factor-1 (LEF1) interacts with the DNA-binding domain of the vitamin D receptor.Semantic proximity Read ↗

Functional mapping of the mouse <i>hairless</i> gene promoter regionSemantic proximity Read ↗

Molecular and functional aspects of the hairless (hr) gene in laboratory rodents and humans.Semantic proximity Read ↗

Hairless and Wnt signaling: allies in epithelial stem cell differentiation.Semantic proximity Read ↗

The "bald Mill Hill" mutation in the mouse is associated with an abnormal, mislocalized HR bmh protein.Semantic proximity Read ↗

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