Article
Hairless and NFκB form a positive feedback loop after UVB and TNFα stimulation.
Photochemistry and photobiology - 1 Jan 2000
Casta Alexandre, Kim Hyunmi, Luke Courtney T, Bachelor Michael A, Engelhard Andrew, Owens David M, Christiano Angela M
Abstract excerpt
Hairless (HR) is a nuclear protein with corepressor activity whose exact function in the skin remains to be determined. Mutations in both human and mouse Hairless lead to hair loss accompanied by the appearance of papules, a disorder called atrichia with papular lesions. Furthermore, mice with mutations in HR are known to have a higher susceptibility to ultraviolet radiation-induced tumorigenesis, suggesting that...
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