Article
Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection.
Molecular and cellular biology - 1 Nov 2005
Ahkter Shamima, Richie Christopher T, Zhang Nianxiang, Behringer Richard R, Zhu Chengming, Legerski Randy J
Abstract excerpt
The eukaryotic SNM1 gene family has been implicated in a number of cellular pathways, including repair of DNA interstrand cross-links, involvement in VDJ recombination, repair of DNA double-strand breaks, and participation in cell cycle checkpoint pathways. In particular, mammalian SNM1 has been shown to be required in a mitotic checkpoint that causes arrest of cells in prophase prior to chromosome condensation...
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