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Article

Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress.

Molecular and cellular biology - 1 Dec 2004

Akhter Shamima, Richie Christopher T, Deng Jian Min, Brey Eric, Zhang Xiaoshan, Patrick Charles, Behringer Richard R, Legerski Randy J

Abstract excerpt

Spindle poisons represent an important class of anticancer drugs that act by interfering with microtubule polymerization and dynamics and thereby induce mitotic checkpoints and apoptosis. Here we show that mammalian SNM1 functions in an early mitotic stress checkpoint that is distinct from the well-characterized spindle checkpoint that regulates the metaphase-to-anaphase transition. Specifically, we found that...

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Identifiers

PMID: 15542852
DOI: 10.1128/MCB.24.23.10448-10455.2004
PMCID: PMC529044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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