Article
NIAM-deficient mice are predisposed to the development of proliferative lesions including B-cell lymphomas.
PloS one - 1 Jan 2014
Reed Sara M, Hagen Jussara, Muniz Viviane P, Rosean Timothy R, Borcherding Nick, Sciegienka Sebastian, Goeken J Adam, Naumann Paul W, Zhang Weizhou, Tompkins Van S, Janz Siegfried, Meyerholz David K, Quelle Dawn E
Abstract excerpt
Nuclear Interactor of ARF and Mdm2 (NIAM, gene designation Tbrg1) is a largely unstudied inhibitor of cell proliferation that helps maintain chromosomal stability. It is a novel activator of the ARF-Mdm2-Tip60-p53 tumor suppressor pathway as well as other undefined pathways important for genome maintenance. To examine its predicted role as a tumor suppressor, we generated NIAM mutant (NIAM(m/m)) mice homozygous...
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