Article
Smg1 haploinsufficiency predisposes to tumor formation and inflammation.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jan 2013
Roberts Tara L, Ho Uda, Luff John, Lee C Soon, Apte Simon H, MacDonald Kelli P A, Raggat Liza J, Pettit Allison R, Morrow Carl A, Waters Michael J, Chen Phil, Woods Rick G, Thomas Gethin P, St Pierre Liam, Farah Camile S, Clarke Raymond A, Brown James A L, Lavin Martin F
Abstract excerpt
SMG1 is a member of the phosphoinositide kinase-like kinase family of proteins that includes ATM, ATR, and DNA-PK, proteins with known roles in DNA damage and cellular stress responses. SMG1 has a well-characterized role in nonsense-mediated decay as well as suggested roles in the DNA damage response, resistance to oxidative stress, regulation of hypoxic responses, and apoptosis. To understand the roles of SMG1...
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