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Article

Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesis.

Cancer research - 1 Nov 2003

Dumon-Jones Valérie, Frappart Pierre-Olivier, Tong Wei-Min, Sajithlal Giangadharan, Hulla Wolfgang, Schmid Gerald, Herceg Zdenko, Digweed Martin, Wang Zhao-Qi

Abstract excerpt

Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive disease characterized by microcephaly, growth retardation, immunodeficiency, chromosomal instability, and predisposition to cancer. Heterozygous NBS patients show increased chromosomal instability and are suspected to be at a high risk for cancer. To study the impact of NBS1 heterozygosity on malignancy susceptibility, we disrupted the murine...

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PMID: 14612522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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