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Article

Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development.

Scientific reports - 7 Jan 2023

Liang Yue, Bhatt Garvit, Tung Lin Tze, Wang HanChen, Kim Joo Eun, Mousa Marwah, Plackoska Viktoria, Illes Katalin, Georges Anna A, Gros Philippe, Henneman Linda, Huijbers Ivo J, Nagar Bhushan, Nijnik Anastasia

Abstract excerpt

Myb-like SWIRM and MPN domains 1 (MYSM1) is a chromatin binding protein with deubiquitinase (DUB) catalytic activity. Rare MYSM1 mutations in human patients result in an inherited bone marrow failure syndrome, highlighting the biomedical significance of MYSM1 in the hematopoietic system. We and others characterized Mysm1-knockout mice as a model of this disorder and established that MYSM1 regulates hematopoietic...

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Identifiers

PMID: 36611064
DOI: 10.1038/s41598-023-27486-7
PMCID: PMC9825392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development.PMID 36611064Read ↗

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