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Article

Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse.

Blood - 1 Apr 2008

Sportoletti Paolo, Grisendi Silvia, Majid Samia M, Cheng Ke, Clohessy John G, Viale Agnes, Teruya-Feldstein Julie, Pandolfi Pier Paolo

Abstract excerpt

Nucleophosmin (NPM1) gene has been heavily implicated in cancer pathogenesis both as a putative proto-oncogene and tumor suppressor gene. NPM1 is the most frequently mutated gene in acute myeloid leukemia (AML), while deletion of 5q, where NPM1 maps, is frequent in patients with myelodysplastic syndromes (MDS). We have previously shown that mice heterozygous for Npm1 (Npm1+/-) develop a hematologic syndrome with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18212245
DOI: 10.1182/blood-2007-06-098251
PMCID: PMC2275037

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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